TNF and inflammatory response: For instance, a large number of NE1 cells were expressed with mature neutrophil markers (e.g., Retnlg, Lcn2, and Asprv1, associated with chronic inflammation) (36, 37), while NE2 cells were highly expressed with pro-inflammatory molecules (e.g., Tnf, Il1b, and Nlrp3, which trigger acute inflammation) (38) (Figures 4B, S6B).