shows that the STING agonist 2’3’-cGAMP does not exist in the serum of SLE patients, and dsDNA is stored in apoptosis derived membrane vesicle, which can effectively prevent the degradation of extracellular nuclease and continuously activate the cGAS-STING signal pathway, promoting the release of some inflammatory factors, including IFN and interleukin-6 (IL-6) (81). This evidence concerns the gene IFNA1 and systemic lupus erythematosus.