STING1 and Aicardi-Goutieres syndrome: AGS is caused by the mutation and deletion of some nuclease genes, which leads to the reduction or loss of nuclease activity, and a good deal of nucleic acids accumulate STING-TBK1-IRF3/NF-κB in the cytoplasm, the excessive activation of these signaling pathways ultimately results in a significant increase in IFN-I levels (43).