NFKB1 and psoriasis: In a study on the in vivo and in vitro anti-psoriasis effects of H-151, a STING antagonist, it was found that local administration of H-151 can alleviate imiquimod induced skin damage in psoriasis and alleviate inflammation by inhibiting the STING/NF-κB in keratinocyte and signal transduction of immune cells, suppresses skin inflammation, and alleviates the symptoms of psoriasis (103).