In a colitis model induced by sodium dextran sulfate (DSS) in mice, compared with WT mice, the colitis symptoms of STING mutant and cGAS-/- mice were obviously reduced, and that the expression level of STING protein is increased in colon M1 macrophages of both DSS-treated WT mice and IBD patients. The gene discussed is CGAS; the disease is inflammatory bowel disease.