STING played a critical role in mediating inflammation response during acute colitis.The protein level of STING was increased in UC and CD patients.STING deficiency alleviated acute experimental colitis in mice, which was associated with the decrease of infiltration of CD45+ leukocyte, CD3+ T cell, F4/80+ macrophage and MPO+ neutrophil in colonic tissues and the expression of pro-inflammatory cytokines. This evidence concerns the gene MPO and colitis.