IRF3 and colitis: ANP can be used as a pharmacologic inhibitor of STING signaling pathway, by targeting pro-inflammatory cytokines and modulating gut barrier dysfunction and ER stress-induced autophagy in UC.cGAS mRNA, p-STING, p-TBK1, and p-IRF3 protein were increased in active UC compared to the remissive UC and the control group.Intraperitoneally injected with ANP ameliorated DSS-induced colitis was associated with the suppression of the STING pathway. The epithelial barrier damage and ER stress-induced autophagy caused by DMXAA in vivo were improved after ANP treatment.