Intratumoral STING activation normalized tumor vasculature and the tumor microenvironment.High endothelial STING expression was correlated with higher CD8+ T cells infiltration and less lymphovascular invasion within colorectal tumor tissues.Intratumoral injection of the STING agonist RR-CDA (also called MIW815 or ADU-S100) combined with VEGRF2 blockade induced tumor regression by enhancing CD8+ T cell infiltration. This evidence concerns the gene CD8A and colorectal neoplasm.