AOM/DSS-treated Cgas-/- mice showed no obvious increase in polyp formation compared to WT mice regardless of the Helico status in their study (110), whereas in another study, Cgas-/- mice displayed higher mortality upon AOM/DSS treatment compared with Stinggt/gt and interferon alpha and beta receptor (Ifnar)-/- mice (107). Here, CGAS is linked to infectious otitis media.