Moreover, tumor sensitivity to PD-1/PD-L1 checkpoint blockade can be enhanced by F. nucleatum supplementation, which induced PD-L1 expression by activating STING signaling and increasing the abundance of IFN-γ+CD8+ tumor-infiltrating lymphocytes in the tumor tissues of BALB/c mice during treatment with PD-L1 blockade (119). This evidence concerns the gene PDCD1 and neoplasm.