Intraperitoneal application of the STING agonist RR-CDA (also known as MIW815 or ADU-S100) alone or combined with an anti-PD-1 antibody enhanced antitumor immunity and normalized aberrant angiogenesis in peritoneal carcinomatosis of colon cancer (144). This evidence concerns the gene PDCD1 and malignant colon neoplasm.