STING had a protective role in the tumorigenesis of CAC.STING was elevated in the colon tissue of CAC patients and protected tumorigenesis by enhancing Syk-mediated pyroptosis of tumor cells.Intraperitoneal injection of STING agonist DMXAA stimulated p-Syk and cleaved GSDMD expression, reduced structural heteromorphism, the number of adenocarcinomas, and increased immune cell infiltration.STING agonist cGAMP reduced cell viability and induced pyroptosis of HT-29 cells through Syk signaling. Here, GSDMD is linked to adenocarcinoma.