Ganciclovir (GCV) may be useful for the treatment of UC through inhibiting STING signaling in colonic macrophages.STING in colon tissues was increased in the affected area of UC patients and the DSS-induced mice model. The mRNA levels of cGAS and STING were increased in CD and UC patients.Intraperitoneal injection of low-dose GCV, an antiviral drug, can ameliorate the symptoms of ulcerative colitis in mice, as evidenced by reduced weight loss, lower disease activity index, and decreased histological damage to the colon tissues, possibly through inhibiting STING activation in macrophages. The gene discussed is CGAS; the disease is ulcerative colitis.