Oxidative stress promoted STING-mediated DCs anti-tumor immune responses.DCs from CRC displayed elevated SENP-IFI16 interaction and decreased IFI16 SUMOylation. DNA-induced interaction between IFI16 and STING was correlated with the increased of p-STING and p-TBK1 in DCs from patients CRC tissues. SENP3 sensed oxidative stress to promote anti-tumor response of DCs in a STING-dependent way. Here, STING1 is linked to neoplasm.