DMD and Becker muscular dystrophy: LVNC in BMD patients has only rarely been reported.<h4>Case report</h4>In the present study, we identified a deletion mutation in exons 10 to 12 (EX10_12 del) of the <i>DMD</i> gene (reference sequence NM_004006.2) in two Chinese siblings with BMD and LVNC by high throughput targeted next-generation sequencing (NGS) and quantitative polymerase chain reaction (qPCR).