This review generalizes the occurrence, development, and related influencing factors of α-syn LLPS, a key pathological protein in PD, and the research progress of LLPS in PINK1-Parkin-mediated mitophagy, starting from the mechanism of the role of biomolecular condensates in the process of α-syn aggregate and mitophagy in PD, and discusses its importance in the development of PD pathology, hoping to provide new ideas and methods for the pathological research of PD. This evidence concerns the gene PRKN and Parkinson disease.