Hypertension is a major risk factor for heart failure, myocardial infarction, stroke, vascular dementia, and other diseases, but the current pharmacotherapiesrelying primarily on diuretics, β-blockers, Ca2+-channel blockers and renin-angiotensin pathway inhibitors—have limited success rates, leaving behind a significant number of patients refractory to treatments. Here, REN is linked to hypertensive disorder.