Murakami and colleagues identified five CAED patients (0.3%) from 1,666 patients with colorectal carcinomas whose clinical pathological features were analyzed followed by IHC staining with enteroblastic lineage markers: glypican-3 (GPC-3), spalt-like transcription factor 4 (SALL4), and AFP (14). This evidence concerns the gene SALL4 and colorectal carcinoma.