Considering the gene expression profile, NKTCL is characterized by overexpression of many genes, including T-related genes (CD2, CD8, CD3G, CD3D, TRAC, LEF1), NF-κB-related genes (BIRC3, NF−κB1, TLR8 and CD27), PD-L1, CD68 as well as downregulation of CD56 (89, 106). This evidence concerns the gene NFKB1 and extranodal nasal NK/T cell lymphoma.