Several polymorphisms and mutation hotspots, such as 15 bp insertion (ins15) that encodes a Janus Kinase 3 (JAK3) motif and the number of 33 bp repeats were associated to specific variants, as well as B cell lymphomas and AIDS-associated B cell lymphomas in specific populations (54, 59, 60, 75, 76). The gene discussed is JAK3; the disease is B-cell non-Hodgkin lymphoma.