In a study involving mice with breast cancer, exercise training increased oxytocin secretion and decreased the activity of the PI3K/AKT axes (Phosphatidylinositol 3-Kinase/Protein Kinase B axes) and ERK axes(Extracellular Signal-Regulated Kinase axes), inhibiting tumor cell proliferation (98). This evidence concerns the gene AKT1 and neoplasm.