IDH2 and malignant glioma: These primary molecularly defined entities are reflected in the WHO CNS5 “pediatric-type diffuse high-grade glioma” family, which includes “diffuse midline glioma, H3 K27-altered”, “diffuse hemispheric glioma, H3 G34-mutant,” and “diffuse pediatric-type high-grade gliomas, H3-, and IDH-wildtype” (16).