The glioma family of “pediatric-type diffuse low-grade glioma” includes: “diffuse astrocytoma, MYB- or MYBL1-altered”, “angiocentric glioma” (MYB::QKI fusions), “polymorphous low-grade neuroepithelial tumor of the young’’ (PLNTY, typically harboring FGFR fusions or BRAF alterations) (27), and “diffuse low-grade glioma MAPK pathway-altered” (BRAF alterations, including BRAF::KIAA1549 and BRAFV600E; and FGFR1 alterations, including point mutations, FGFR1 fusions and tyrosine kinase domain duplications) (16). This evidence concerns the gene MYBL1 and central nervous system cancer.