To validate if miR-379 levels in PCa cells could impact GDF-15 secretion by bone cells, we performed an ELISA using MG-63 cells grown in conditioned media from both miR-379-overexpressing PC3 cells and conditioned media from anti-miR-379-transduced 22Rv1 cells, with respective controls. Here, GDF15 is linked to posterior cortical atrophy.