MAPT and Alzheimer disease: Specifically, it is suggested that fungal PSs benefit AD a lot, including reducing the aggregation of Aβ peptides and tau proteins (7, 60, 61, 71), eliminating excessive oxidative stress (7, 60–62, 71), pro-inflammatory (41, 48), and restoring dysregulated neuroplasticity (7, 60, 62, 64, 71) (Figures 2, 3).