Zhu et al. (26) reported that treatment with bixin (50, 100 mg/kg/day for 6 or 14 days) attenuated the expression of p-PI3K, p-Akt and p-mammalian target of rapamycin (mTOR) in the lungs of acute, chronic as well as steroid-resistant asthma in Balb/c mice. This evidence concerns the gene AKT1 and asthma.