Importantly, reduced BDNF, and increased total glucocorticoid receptor (GR) and phosphorylated GR (at serine 211) in depression animals were also reversed by PRE (Lim et al., 2022), suggesting an antidepressant effect of P. resupinata through the BDNF-and/or GR-mediated molecular mechanism. The gene discussed is NR3C1; the disease is depressive disorder.