Importantly, reduced BDNF, and increased total glucocorticoid receptor (GR) and phosphorylated GR (at serine 211) in depression animals were also reversed by PRE (Lim et al., 2022), suggesting an antidepressant effect of P. resupinata through the BDNF-and/or GR-mediated molecular mechanism. This evidence concerns the gene BDNF and major depressive disorder.