TRIM28 and cancer: Furthermore, the major genetic alterations in the TRIM28 gene were missense mutation, amplification, and deep deletion (Figure 4B), and the integrated TRIM28 mutation data in the pan-cancer context are presented in Figure 4C. Moreover, we analyzed the relationships between TRIM28 genetic alterations and clinical prognosis and found that the OS time of the altered group was considerably shorter than that of the unaltered group in PRAD (p < 0.001) and UCS (p < 0.001), indicating that TRIM28 genetic alteration is related to worse prognosis (Figure 4D).