Our results support the immunosuppressive functions of BIRC2 by demonstrating a strong association between the expression of BIRC2 and the expression of immunological molecules in HCC, which indicates that BIRC2 plays a crucial role in tumor immunity and is a promising biomarker for predicting the prognosis and effectiveness of immunotherapy in patients with HCC. Here, BIRC2 is linked to hepatocellular carcinoma.