MAPK8 and colorectal cancer: Nonetheless, Tai et al. 73 reported that Gynostemma pentaphyllum saponins (GpS) hinder the development of colorectal cancer by upregulating PRDX1 and PRDX2, inhibiting the Ras, RAF/MEK/ERK/STAT, PI3K/AKT/mTOR signaling pathways, and regulating the JNK/p38 MAPK signaling pathway.