The increase of Immunohistochemical (IHC) staining in TUNEL, BCL-2 and Caspase-3 reflected AhR deficiency downregulation induced apoptosis in the proliferation of adenocarcinoma cells of AOM/DSS mice (Supplementary Figure 4D). These results suggested that AhR deficiency protected against AOM/DSS-induced colitis-associated CRC. The gene discussed is AHR; the disease is infectious otitis media.