Thus, this study reveals a novel metastatic mechanism of GC that RHOJ induces EMT by IL-6/STAT3 to promote invasion and metastasis in GC (Figure 8), and RHOJ is identified as a new oncogene that induces GC metastasis and may become a promising prognostic marker and therapeutic target for EMT-subtype GC patients. This evidence concerns the gene RHOJ and gastric cancer.