Although STING was involved in innate immune activation 33, IFN regulators were inactivated in SAMHD1-KD DLBCL cells, including TANK-binding kinase 1 (TBK1) and interferon regulatory factor 3 (IRF3) (Figure 3C, Figure S4A). This evidence concerns the gene TBK1 and diffuse large B-cell lymphoma.