CLDN2 and colitis: Consistent with these results, Compound C treatment significantly reduced the levels of tight junction proteins ZO-1, ZO-2, occludin, and claudin-3 and increased claudin-2 levels in colon tissues of P2Y1R-/- colitis mice (Figure 8G-8I). Taken together, these results suggest that AMPK activation mediates the beneficial effects of P2Y1R inhibition in promoting intestinal mucosa repair.