PACS2 and diabetic kidney disease: Zhao et al. found that diabetic mice with proximal tubule PACS2-specific knockout had more severe tubular damage and proteinuria than controls, which was accompanied by increased lipid synthesis, decreased cholesterol uptake and efflux, and lipid deposition in renal tubules 111, indicating that PACS2 is a major regulator in lipid-related kidney lesions in DKD.