We further confirmed the effect of PBX3 on G6PD protein level and found that knocking down PBX3 robustly suppressed the protein level of G6PD in colon cancer cells HCT116, hepatocellular carcinoma cells HCC-LM3, and breast cancer cells MCF-7 (Figure 1F), while overexpressing PBX3 conspicuously increased G6PD protein levels in these cells (Figure 1G). The gene discussed is G6PD; the disease is hepatocellular carcinoma.