While whether PBX3 interacts with other factors in regulating G6PD transcriptional activity, or whether it could also regulate G6PD transcriptional activity through epigenetic regulation needs further investigation, our current study not only unravel a new mechanism regarding the oncogenic activity of PBX3, but also reveals a novel mechanism of G6PD/PPP activation in tumor cells. Here, PBX3 is linked to neoplasm.