NOTCH3 and neoplasm: Furthermore, it could also activate the transcription of tumor-initiating cells-related genes, including calcium voltage-gated channel auxiliary subunit alpha 2 delta 1 (CACNA2D1), epithelial cell adhesion molecule (EpCAM), SRY-box transcription factor 2 (SOX2), and notch receptor 3 (Notch3), thereby promoting the self-renewal ability of tumor-initiating cells 21.