In addition, other bacterial factors have been suggested to be involved in AD pathology such as lipopolysaccharides (LPS) from Gram-negative bacteria, which can induce a neuroinflammation (Zhan et al., 2018), bacterial extracellular DNA which may promote Aβ and tau aggregation (Tetz et al., 2020; Tetz and Tetz, 2021), or microbial amyloid proteins, which could trigger the propagation of misfolded endogenous proteins in a prion-like manner and enhance the inflammatory response (Chen et al., 2016; Friedland and Chapman, 2017). The gene discussed is MAPT; the disease is Alzheimer disease.