NFE2L2 and Sepsis: In a sepsis model induced by cecal ligation and puncture, dexmedetomidine upregulates the expression of glucose-6-phosphate dehydrogenase by nuclear factor erythroid 2-related factor 2 (Nrf2) and activates the pentose phosphate pathway, thereby increasing GPX4 and GSH activities, boosting free radical scavenging, and inhibiting lipid peroxidation and ferroptosis [18].