EA treatment at Bai hui (GV20), Da zhui (GV14) starting 1 day after cerebral ischemia–reperfusion effectively increased BDNF expression, provided BDNF-mediated neuroprotection and prevented caspase-3-dependent neuronal apoptosis through phosphorylation of Raf-1/MEK1/2/ERK1/2/p90RSK/Bad signaling cascade (70). This evidence concerns the gene BDNF and brain ischemia.