Furthermore, cancer is also characterized by inflammation, which can reduce HDL-C levels in various ways; namely by the action of endotoxins and cytokines, the suppression of apoA-I production by the liver, the increases in endothelial cell lipase and secretory phospholipase A2, and the impairment in Lecithin:cholesterol acyltransferase (LCAT) function [43]. The gene discussed is PLA2G2D; the disease is cancer.