We explored how macrophages shield lesions from immune surveillance while promoting pathological cell growth, invasion, and metastasis (32), and identified 9 key macrophage genes, including GINS3, PRMT2, MERTK, WWP2, NEK6, NACC1, NR1H3, ATP2A2, and TM4SF19, some of which have not been previously reported in the context of endometrial cancer. The gene discussed is NACC1; the disease is endometrial cancer.