LEP and Obesity: Leptin, a notable adipokine secreted from adipose cells,16 is a proinflammatory cytokine associated with asthma.17, 18, 19, 20 Obesity increases leptin secretion, which induces airway inflammation and may lead to the development of asthma,17, 18, 19, 20 whereas the level of adiponectin, which has anti-inflammatory effects, has been reported to decrease in obese people.21