These above contradictory results of autophagy and Beclin1 in ICC indicated that, even in the same tumor, due to the heterogeneity and molecular aberrations distinct [39], the characteristics of autophagy might be distinguished among the various cell strains, different developmental stages, and diverse contexts [40], suggesting more molecular biomarker identification may be benefit for better understanding the intrinsic mechanism of autophagy in ICC. The gene discussed is BECN1; the disease is intrahepatic cholangiocarcinoma.