The result of negative regulation of oncogene COTE1 on Beclin1 in our experiment was consistent with the findings of Han et al. [12]; the oncogene TRIM59 could negatively regulate autophagy via modulating both the transcription and the ubiquitination of Beclin1 in non-small-cell lung cancer (NSCLC). Here, BECN1 is linked to non-small cell lung carcinoma.