To further verify that TLR7 regulates NFκB signaling in rosacea, we performed immunofluorescence staining on mouse skin lesions and found cathelicidin LL37 increased the expression of p-p65 in epidermis, which was not apparent in Tlr7 siRNA mice (Figs. 3E and 3F). The gene discussed is TLR7; the disease is rosacea.