In consideration of the chemotactic effect of chemokines on immune cells, as well as the enrichment of immune cells in rosacea lesions, we performed CD4 immunostaining and found infiltration of CD4+ T cells induced by LL37 was eliminated by Tlr7 siRNA in the dermis of rosacea-like mice (Figs. S4A and S4B). The gene discussed is TLR7; the disease is rosacea.