AKT1 and neurodegenerative disease: Interestingly, the deletion of NOX2 in a mouse model of ALS, another MN neurodegenerative disease, was shown to induce efficient AKT activation in the mouse spinal cord associated with (i) a significant neuroprotection of the spinal MNs, (ii) a limitation of microgliosis and (iii) an extension of ALS mouse lifespan (Wu et al., 2006).