CLC and bronchiectasis: In continuation, patients with bronchiectasis had a significantly higher, albeit only using single comparison and not multiple regression, level of messenger RNA expression of CLC—which has been linked to mucus plug formation—and been reported increased in the peripheral blood of patients with aspirin-induced asthma and in the nasal lavage fluid of patients with aspirin-sensitive respiratory disease, which widely are regarded as traits of the predominantly IL-5–related late-onset eosinophilic phenotype.27, 28, 29, 30, 31