Pathogenic variants of the JAM3/JAM-C gene were first reported in 2010 (1) and 2013 (2) to cause the rare recessive disorder called hemorrhagic destruction of the brain, subependymal calcification, and cataracts (HDBSCC, OMIM#613730) by mimicking an intrauterine toxoplasma, rubella, cytomegalovirus, Herpes simplex, and HIV (TORCH) infection. This evidence concerns the gene JAM3 and cataract.