Subsequentin vitro experiments using glioblastoma and neuroblastoma cell lineshave revealed that both CZ and RP effectively inhibited their proliferation,and qRT-PCR has shown that CZ upregulated the expression of the p53-regulatedgenes involved in cell cycle arrest, apoptosis, and DNA damage response.These findings show that CZ can be an effective p53 activator in vitro,and given its known safety profile and approval status, it could easilybe translated into a clinical treatment method if the results arereproducible in vivo. Here, TP53 is linked to glioblastoma.