MMP13 and osteoarthritis: Upregulation of lncRNA TUG1 suppressed the miR-195 expression and inhibited the expression of collagen and aggrecan, whereas lncRNA TUG1 overexpression promoted the expression of MMP-13, indicating that TUG1 might promote degradation of chondrocyte extracellular matrix in osteoarthritis by regulation of miR-195 and MMP-13 (Tang et al., 2018).