It is thought that the elevation of BP in PHA2 patients may partially due to increasing reabsorption of water and sodium via L-WNK1/KS-WNK1 mediated upregulation of Na-Cl cotransporter (NCC), resulting volume expansion-induced hypertension (Vidal-Petiot et al., 2013; Brown et al., 2021; Meor Azlan et al., 2021). This evidence concerns the gene SLC12A3 and pseudohypoaldosteronism type 2.