Benzyl isothiocyanate enhances Nrf2-dependent antioxidant defense, mediates skeletal muscle IRS-1/AKT/TBC1D1 signalling, and improves GLUT4 expression, thereby ameliorating high-fat diet-induced hyperglycemia (Chuang et al., 2020). Here, NFE2L2 is linked to Hyperglycemia.