NFE2L2 and metabolic dysfunction-associated steatotic liver disease: The loss of Nrf2 in mice leads to an increased incidence of tumors (Kensler et al., 2007; Tao et al., 2018), and the liver-specific activation of Nrf2 controls fibrosis and carcinogenesis in non-alcoholic fatty liver disease (Mohs et al., 2021).