CiteSpace categorized the relevant clusters into 20 groups (shown in Figure 8D), encompassing various topics such as Nrf2 mutation, cigarette smoking, p62-dependent autophagic degradation, bardoxolone methyl, young grass carp, antioxidant induction, catalytic subunit gene, Nrf2-dependent mechanisms, alpha receptor, major metabolite receptor, cellular apoptosis, rat brain, Keap1 loss, inhibiting ferroptosis, non-alcoholic fatty liver disease gene, redox control, protein-protein interaction, melanoma cell, nf-e2 related factor, and oxygenase-1 expression. The gene discussed is KEAP1; the disease is melanoma.