One research has revealed that transfection of human granulosa cells with siRNA targeting HSP90AB1 mRNA reduced autophagy and alleviated endoplasmic reticulum stress, while the autophagy inhibitor 3-MA reversed the above process (Wu Y. et al., 2018), implicating a functional relationship between HSP90AB1 and autophagy in RA. The gene discussed is HSP90AB1; the disease is rheumatoid arthritis.