Promoter methylation was lower in PAAD than normal pancreatic tissues for all three genes (LAMA3 normal β:0.43, tumour β:0.34, p = 2.8 × 10−9; LAMB3 normal β:0.65, tumour β:0.53, p = 8.6 × 10−7; and LAMC2 normal β:0.44, tumour β:0.38, p = 0.04) (Figure 7A). This evidence concerns the gene LAMB3 and neoplasm.