We are not aware of studies at this time analysing the direct association between the purinergic receptor P2RY2 and PAAD; this receptor is known to upregulate selinexor, which, in turn, activates PI3K/AKT signalling in acute myeloid leukaemia (Lin et al., 2022). This evidence concerns the gene AKT1 and pancreatic adenocarcinoma.