Targeting the Lands Cycle through lysophosphatidylcholine acyltransferase 3 (LPCAT3) or phospholipase A2 group IVC (PLA2G4C) inhibition resulted in increased ferroptosis, indicating that proper functioning of the Lands Cycle is necessary to prevent cell death in KRAS-mutant lung cancer (Bartolacci et al., 2022). The gene discussed is PLA2G4C; the disease is lung carcinoma.