Nonetheless common genetic and signaling pathways such as p53 should also be considered in the colitis associated cancer spectrum, inflammation can induce the production of pro inflammatory cytokines that can induce mutation in oncogenes such as p53, APC, K-ras and genomic instability by different mechanism promoting tumor proliferation and antiapoptotic properties or premalignant cells 30. The gene discussed is KRAS; the disease is cancer.