According to the study of Dong et al, cancer cells expressing PD-L1 can induce apoptosis in activated T-cells and prompt circulating T-cells to produce IL-10, resulting in a suppressed immune response [9]. Apart from its ability to induce T-cell apoptosis and interleukin-10 (IL-10) production, PD-L1 also has various impacts on T-cell activity [10]. The gene discussed is CD274; the disease is cancer.