However, increased levels of inflammatory cytokines and the activation of lymphocytes might increase the severity of GVHD [15,16]. Several trials, analyzing the use of G-CSF after ASCT, have shown a significant acceleration in neutrophil recovery, without an increase in the incidence and severity of GVHD, but some trials found an increase in GVDH. The gene discussed is CSF3; the disease is graft versus host disease.