Genomic studies in patients with autism spectrum disorders, epilepsy or intellectual deficiency have identified pathogenic mutations in multiple Rho GTPases-encoding genes, but also in various Rho GTPase regulators and effectors (RAC1, CDC42, PAK; Michaud et al., 2014; Tastet et al., 2019; Barbosa et al., 2020; Halder et al., 2022; Dobrigna et al., 2023). This evidence concerns the gene RAC1 and epilepsy.