Primary immunodeficiencies transplanted include severe combined immunodeficiencies, Wiskott-Aldrich syndrome, leukocyte adhesion deficiency (aka LAD), HLH, combined immunodeficiencies (deficiencies in hyper-IgM or dedicator of cytokinesis 8, aka DOCK8) and immune dysregulation (LRBA deficiency, CTLA4 deficiency, and IPEX syndrome). Here, DOCK8 is linked to immunodeficiency disease.