Furthermore, hyperglycemia induced persistent changes in chromatin accessibility and histone methylation and acetylation (i.e., increased H3K4me3 and H3K27ac) at relevant genomic loci including key genes in inflammation (Il‐6) and glucose metabolism (hexokinase 1; Hk1), which led to increased transcriptional activation in diabetic hematopoietic stem cells (HSCs) and differentiated macrophages.12 This evidence concerns the gene HK1 and Hyperglycemia.