These may explain the results from our study that upon MET-positive tumor cell stimulation, MET-CAR.CD28ζ T cells overall produced higher levels of cytokines than MET-CAR.4-1BBζ T cells in vitro, significantly inhibited MHCC97H tumor growth with higher efficacy than MET-CAR.4-1BBζ T cells in vivo for the first 2 weeks, but the difference of growth inhibition diminished thereafter (Fig. 5B, C). The gene discussed is MET; the disease is neoplasm.