With MHCC97H cells, HS-derived MET-CAR.CD28ζ and MET-CAR.4-1BBζ T cells showed higher killing efficacy than those from HCC patients with E:T ratios = 2.5:1 and 1.25:1 (student t test, p < 0.05). This evidence concerns the gene MET and hepatocellular carcinoma.