A one-time tail-vein injection of MET-CAR.CD28ζ T cells (5 × 106 cells) induced tumor regression after day 14 and significantly inhibited MHCC97H orthotopic tumor growth in 4 out of 7 mice for 90 days while control mice were sacrificed on day 29 due to tumor progression (Fig. 6B, C). Here, MET is linked to neoplasm.