The methylation degree of ZNF471 was more than 2.9-fold, SND1 was more than 14.5-fold, SPOCK1 was more than 5.8-fold, FBLIM1 was more than 11.1-fold, and OTX1 was more than 6.9-fold in colorectal cancer or colorectal adenoma to that in the normal control. This evidence concerns the gene SND1 and colorectal cancer.