RHOJ and neoplasm: Next, RHOJ affinity purification (AP) and mass spectrometry (MS) characterization have been performed by Debaugnies and colleagues to uncover how RHOJ regulates DNA repair and replication after chemotherapy.1 Based on the AP-MS and co-immunoprecipitation results, they identified IPO9-a protein that mediates the nuclear import of actin-was enriched and interacted with RHOJ in EMT tumor cells after chemotherapy.